Grosse Point Farms Chronic Inflammatory Response Syndrome: Chronic Inflammatory Response Syndrome (CIRS) is a progressive, multi-system, multi-symptom illness characterized by exposure to biotoxins. The ongoing inflammation can affect virtually any body organ system and, if left untreated, becomes debilitating. Chronic Inflammatory Response Syndrome (CIRS) is a progressive, multi-system, multi-symptom illness characterized by exposure to biotoxins. The ongoing inflammation can affect virtually any body organ system and, if left untreated, becomes debilitating.